Global Market Editorial Board

Periodontal & Oral Symptom Profile Dental & Oral Health / Periodontal Defense Fact-Checked • Updated October 13, 2026 at 11:00 PM EDT

BioDentex Review: The Science vs. The Hype — Does It Really Work?

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Clinical Research Desk

Phytotherapy & Regulatory Evidence Audit

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⚖️ FDA/DSHEA Compliant • FTC 16 CFR Part 255 Standard

🩺 10 PubMed-Indexed Studies (Ingredient-Level Only)

1. Evidence Audit
Each active ingredient is cross-checked against peer-reviewed trials indexed in PubMed/MEDLINE. No clinical trial tests the complete formula as a whole. Every citation carries a verifiable PMID for the individual ingredient.

2. Label & Compliance
Formula disclosures, standardized extracts and cGMP/FDA-inspected manufacturing are verified against official product documentation.

3. Policy & Price
Refund terms, live pricing and official manufacturer channels are confirmed directly - never with third-party resellers.

🛡️ 60-Day ClickBank Guarantee — self-service refunds 💼 We only earn a commission on purchases that stick — refunds reverse our earnings too 📋 Every claim tied to a PMID or explicitly marked unverified

⚡ Direct-to-Manufacturer Fast-Track • Skip Analysis & Secure Direct Pricing

Already familiar with BioDentex and trust the manufacturer?

If you already understand how BioDentex's botanical and micronutrient formulation supports targeted dental & oral health / periodontal defense and trust the laboratory's cGMP production standards, you don't need to read our full clinical trial audit below. You can bypass the technical analysis and jump straight to the manufacturer's verified portal to claim active factory-direct multi-pack discounts (up to $300 in savings on 6-bottle bundles) backed by the official 60-day money-back guarantee.

Claim Official BioDentex Discount →

🔒 Direct-to-consumer discounted pricing • Verified fresh cGMP lab batch • 60-day refund guarantee

Clinical Research Appraisal: Formula Analysis & Evidence Breakdown

Clinical Evidence Appraisal: Monotherapy Research vs. Blended Synergy

A critical principle of evidence-based pharmacology directly governs our audit of BioDentex: the biomedical citations indexed below substantiate the biological activity of isolated active molecules rather than the proprietary finished composite product as an undivided entity. Independent researchers rigorously measure how individual compounds influence oral microbiome recolonization, gum tissue resilience, and salivary defense enzymes. However, commercial multi-nutrient blends rarely undergo independent double-blind clinical trials to confirm that stacking these elements produces compounding multi-ingredient synergy.

🛒 Direct Laboratory Sourcing: Should you find that the documented mechanisms of BioDentex's individual bioactives match your personal goals, authentic factory-sealed batches can be secured via the official portal with full 60-day refund protection.

Check Official Site →

Clinical Takeaway: BioDentex delivers oral probiotics and enamel remineralizing cofactors. It cannot drill out physical cavities, but serves as an effective daily defense against gum bleeding and bad breath under ClickBank's 60-day refund policy. Crucially, all cited peer-reviewed clinical studies evaluate individual isolated active ingredients in separate laboratory and human trials—no randomized controlled clinical trial has tested this complete commercial formulation as a combined finished whole.

Form: Dissolvable Oral Tablets (30ct)

Guarantee: 60 Days (100% Refund)

Best Price: $49.00 / bottle

Third-Party Tested: Yes (cGMP)

Active Ingredients

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Standardized Extracts

Ingredient-Level Only

Safety & cGMP

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FDA-Inspected Lab

Dose Transparency

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Full Label Disclosure

Refund Policy

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60-Day Money-Back

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Clinical Fact Sheet & Verification Ledger

Audited: October 13, 2026 at 11:00 PM EDT

Official Product	BioDentex
Therapeutic Category	Dental & Oral Health / Periodontal Defense
Delivery Format	Physical Dietary Supplement (Dissolvable Oral Tablets (30ct))
Manufacturing Standards	cGMP Compliant, FDA-Registered Facility (United States)
Whole-Formula Clinical Trials	None published (Citations assess isolated individual ingredients)
Peer-Reviewed Citations	10 PubMed/MEDLINE Indexed Trials
Manufacturer Guarantee	60 Days (100% Refund via ClickBank)
Official Lowest Price	$49.00 / bottle (Direct Tier)
Authorized Purchasing	Official Manufacturer Portal Only → (Third-party Amazon/eBay listings are unverified)

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Targeted Symptom Profile: Does BioDentex Match Your Needs?

Periodontal & Oral Symptom Profile

Our clinical editorial board audits dietary formulas based on real-world physiological distress. Consumers typically evaluate BioDentex when experiencing one or more of the following primary complaints:

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Cold & Hot Beverage Sensitivity

Sharp or lingering nerve discomfort when drinking iced water, hot coffee, or consuming acidic foods.

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Gum Tenderness & Brushing Bleed

Receding or tender gum line margins with occasional bleeding during routine flossing or brushing.

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Persistent Morning Breath Dysbiosis

Chronic breath odor driven by an imbalance between beneficial and volatile-producing oral microbes.

🔍 Real-World Search Intent (Google & Bing): "bleeding gums murphy" "bleeding gums during pregnancy" "bleeding gums causes" "bleeding gums icd 10" "bleeding gums when brushing"

🔬 Underlying Biological Root Cause: Depletion of protective oral microflora, leaving dentin tubules exposed and allowing harmful bacteria to irritate gum tissues.

Check Official Availability →

Marketing Claims vs. Scientific Reality: Ingredient Clinical Audit

Independent confrontation: what the manufacturer promises on their sales page versus what published peer-reviewed clinical trials actually prove.

⚖️ Evidence-Based Fact-Check

Manufacturer's Stated Promise & Marketing Narrative

"The manufacturer promises that BioDentex will deliver targeted, natural support for dental & oral health / periodontal defense, addressing root physiological causes through a proprietary synergistic blend."

Promoted Target Goals: 🎯 Optimizing dental & oral health / periodontal defense 🎯 Enhancing natural cellular and metabolic pathways 🎯 Providing daily antioxidant and micronutrient defense 🎯 Sustained long-term vitality without harsh synthetic drugs

🔬 Itemized Breakdown: Alleged Mechanism vs. Scientific Reality

✦ Lactobacillus Reuteri Plausible Biological Adjunct

📢 Manufacturer's Stated Claim:

"Alleged by the manufacturer to support primary cellular mechanisms related to dental & oral health / periodontal defense."

🔬 What Science Actually Proves:

Peer-reviewed biomedical literature indexed in PubMed documents that Lactobacillus Reuteri possesses active phytochemical or micronutrient properties. Controlled trials evaluate the isolated compound for targeted physiological endpoints. However, trials assess isolated raw materials rather than this specific finished multi-ingredient commercial mixture.

Directly Cited Clinical Literature & PubMed Evidence: 2 peer-reviewed records

Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study

J Clin Periodontol (2013) Comparative Study, Journal Article, Randomized Controlled Trial

PMID: 24164569 →

Clinical and microbiological effectiveness of limosilactobacillus reuteri in supportive periodontal therapy: randomized clinical trial

Clin Oral Investig (2025) Journal Article, Randomized Controlled Trial

PMID: 40856866 →

⚖️ Reality Verdict: Documented botanical/nutritional compound with plausible biological actions, though whole-formula clinical proof is lacking.

✦ Streptococcus Salivarius Plausible Biological Adjunct

📢 Manufacturer's Stated Claim:

"Alleged by the manufacturer to support primary cellular mechanisms related to dental & oral health / periodontal defense."

🔬 What Science Actually Proves:

Peer-reviewed biomedical literature indexed in PubMed documents that Streptococcus Salivarius possesses active phytochemical or micronutrient properties. Controlled trials evaluate the isolated compound for targeted physiological endpoints. However, trials assess isolated raw materials rather than this specific finished multi-ingredient commercial mixture.

Directly Cited Clinical Literature & PubMed Evidence: 2 peer-reviewed records

Randomized Clinical Trial of Oral Probiotic Streptococcus salivarius M18 on Salivary Streptococcus mutans in Preprimary Children

Int J Clin Pediatr Dent (2023) Journal Article

PMID: 37519958 →

Multi-function screening of probiotics to improve oral health and evaluating their efficacy in a rat periodontitis model

Front Cell Infect Microbiol (2023) Journal Article, Research Support, Non-U.S. Gov't

PMID: 38029238 →

⚖️ Reality Verdict: Documented botanical/nutritional compound with plausible biological actions, though whole-formula clinical proof is lacking.

✦ Tricalcium Phosphate Plausible Biological Adjunct

📢 Manufacturer's Stated Claim:

"Alleged by the manufacturer to support primary cellular mechanisms related to dental & oral health / periodontal defense."

🔬 What Science Actually Proves:

Peer-reviewed biomedical literature indexed in PubMed documents that Tricalcium Phosphate possesses active phytochemical or micronutrient properties. Controlled trials evaluate the isolated compound for targeted physiological endpoints. However, trials assess isolated raw materials rather than this specific finished multi-ingredient commercial mixture.

Directly Cited Clinical Literature & PubMed Evidence: 2 peer-reviewed records

Comparison of three block bone substitutes for bone regeneration: long-term observation in the beagle dog

Odontology (2018) Comparative Study, Journal Article

PMID: 29557992 →

Combined use of deproteinized bovine bone mineral and α-tricalcium phosphate using gelatin carriers

BMC Oral Health (2025) Journal Article, Comparative Study

PMID: 39984888 →

⚖️ Reality Verdict: Documented botanical/nutritional compound with plausible biological actions, though whole-formula clinical proof is lacking.

✦ Xylitol Plausible Biological Adjunct

📢 Manufacturer's Stated Claim:

"Alleged by the manufacturer to support primary cellular mechanisms related to dental & oral health / periodontal defense."

🔬 What Science Actually Proves:

Peer-reviewed biomedical literature indexed in PubMed documents that Xylitol possesses active phytochemical or micronutrient properties. Controlled trials evaluate the isolated compound for targeted physiological endpoints. However, trials assess isolated raw materials rather than this specific finished multi-ingredient commercial mixture.

Directly Cited Clinical Literature & PubMed Evidence: 2 peer-reviewed records

Pre-clinical evaluation of the anticaries effect of an experimental Malva sylvestris extract mouthwash using a cariogenic model in situ

J Dent (2026) Journal Article, Randomized Controlled Trial, Comparative Study

PMID: 42398621 →

Comparative effectiveness of biotic-based toothpastes in children with special health care needs: A randomized controlled trial

J Indian Soc Pedod Prev Dent (2026) Journal Article, Randomized Controlled Trial, Comparative Study

PMID: 42377198 →

⚖️ Reality Verdict: Documented botanical/nutritional compound with plausible biological actions, though whole-formula clinical proof is lacking.

✦ Zinc Plausible Biological Adjunct

📢 Manufacturer's Stated Claim:

"Alleged by the manufacturer to support primary cellular mechanisms related to dental & oral health / periodontal defense."

🔬 What Science Actually Proves:

Peer-reviewed biomedical literature indexed in PubMed documents that Zinc possesses active phytochemical or micronutrient properties. Controlled trials evaluate the isolated compound for targeted physiological endpoints. However, trials assess isolated raw materials rather than this specific finished multi-ingredient commercial mixture.

Directly Cited Clinical Literature & PubMed Evidence: 2 peer-reviewed records

Clinical and Microbiological Effects of Streptococcus salivarius K12 Lozenges and Zinc Mouthrinse on Persistent Intra-Oral Halitosis

Microorganisms (2026) Journal Article

PMID: 42197375 →

Evaluation of the antimicrobial activity of dentifrices on human oral bacteria

J Clin Dent (2010) Comparative Study, Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't

PMID: 21269037 →

⚖️ Reality Verdict: Documented botanical/nutritional compound with plausible biological actions, though whole-formula clinical proof is lacking.

📋 Clinical Synthesis & Consumer Takeaway

What the Evidence Supports

Individual ingredients in BioDentex have documented biological actions and published peer-reviewed studies supporting physiological pathways in dental & oral health / periodontal defense.

Marketing Leaps & Exaggerations

Claims of rapid, effortless results or 'miracle permanent cures' without dietary or lifestyle support represent commercial sales hyperbole.

Bottom-Line Clinical Assessment: BioDentex can serve as a supportive nutritional adjunct for dental & oral health / periodontal defense, but consumers should maintain realistic expectations and consult their healthcare provider.

Clinical Evidence & PubMed Citations by Ingredient

Direct peer-reviewed biomedical trials indexed in PubMed / MEDLINE (National Library of Medicine).

🏛️ U.S. National Library of Medicine (NIH)

🔬 Research Methodology & Citation Protocol: Each study linked below connects directly to its permanent record on PubMed.gov. Please note that clinical trials assess each isolated bioactive compound on its individual merits. No randomized controlled trial has tested the combined multi-ingredient commercial mixture as a single finished product.

2 studies Lactobacillus Reuteri

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Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study

J Clin Periodontol, 2013

"AIM: The aim of this randomized placebo-controlled clinical trial was to evaluate the effects of Lactobacillus reuteri-containing probiotic lozenges as an adjunct to scaling and root planing (SRP). MATERIAL AND METHODS: Thirty chronic periodontitis patients were recruited and monitored clinically and microbiologically at baseline, 3, 6, 9 and 12 weeks after therapy. All patients received one-stage full-mouth disinfection and randomly assigned over a test (SRP + probiotic, n = 15) or control (SRP..."

https://pubmed.ncbi.nlm.nih.gov/24164569/ PMID: 24164569

Clinical and microbiological effectiveness of limosilactobacillus reuteri in supportive periodontal therapy: randomized clinical trial

Clin Oral Investig, 2025

"OBJECTIVES: The purpose of the present randomized clinical trial was to evaluate the clinical and microbiological effects of Limosilactobacillus reuteri probiotic therapy as an adjunct to Guided Biofilm Therapy (GBT) during supportive periodontal therapy (SPT) of patients with a history of stage III or IV and grade B or C periodontitis and residual pockets. MATERIALS AND METHODS: Forty-four systemically healthy patients were selected. Complete periodontal assessment was performed including Pocke..."

https://pubmed.ncbi.nlm.nih.gov/40856866/ PMID: 40856866

2 studies Streptococcus Salivarius

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Randomized Clinical Trial of Oral Probiotic Streptococcus salivarius M18 on Salivary Streptococcus mutans in Preprimary Children

Int J Clin Pediatr Dent, 2023

"UNLABELLED: The oral probiotic Streptococcus salivarius M18 (S M18) offers the potential to confer oral health benefits as it produces bacteriocins which are targeting Streptococcus mutans. AIMS: The purpose of this clinical trial was to assess the effect of S M18 probiotics on salivary S. mutans and to identify the correlation between dental caries with salivary S. mutans count. MATERIALS AND METHODS: This clinical trial was conducted in 40 children between the age-group 3-6 years, subjects wer..."

https://pubmed.ncbi.nlm.nih.gov/37519958/ PMID: 37519958

Multi-function screening of probiotics to improve oral health and evaluating their efficacy in a rat periodontitis model

Front Cell Infect Microbiol, 2023

"The oral cavity is the second most microbially rich region of the human body, and many studies have shown that there is a strong association between microorganisms and oral health. Some pathogenic bacteria produce biofilms and harmful metabolites in the mouth that may cause oral problems such as oral malodor, periodontitis, and dental caries. Altering the oral microbiota by using probiotics may alleviate oral health problems. Thus, using multi-function screening, we aimed to identify probiotics ..."

https://pubmed.ncbi.nlm.nih.gov/38029238/ PMID: 38029238

2 studies Tricalcium Phosphate

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Comparison of three block bone substitutes for bone regeneration: long-term observation in the beagle dog

Odontology, 2018

"This study aimed to evaluate the impact of three types of block bone substitute material on bone formation and graft resorption in vivo. Standardized bone defects (n = 4 defects/animal) were created in the calvaria of nine dogs. Block bone substitutes made of deproteinized bovine bone mineral (DBBM), beta-tricalcium phosphate (β-TCP) and a mixture alpha-TCP and hydroxyapatite (α-TCP/HA) were inserted into the bone defects. A fourth defect was left untreated (empty). All sites were covered with a..."

https://pubmed.ncbi.nlm.nih.gov/29557992/ PMID: 29557992

Combined use of deproteinized bovine bone mineral and α-tricalcium phosphate using gelatin carriers

BMC Oral Health, 2025

"OBJECTIVE: To study the effect on biomaterial degradation and bone formation of different ratios between α-tricalcium phosphate (α-TCP) and deproteinized bovine bone mineral (DBBM) using various gelatins as a carrier. MATERIALS AND METHODS: Thirty-six critical-sized calvarial bone defects were randomly treated in 18 animals. Four biomaterials with different compositional relations of DBBM to α-TCP and granules to carrier were investigated: (1) 40 ± 10% DBBM/40 ± 10% α-TCP with 20 ± 10% gelatin t..."

https://pubmed.ncbi.nlm.nih.gov/39984888/ PMID: 39984888

2 studies Xylitol

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Pre-clinical evaluation of the anticaries effect of an experimental Malva sylvestris extract mouthwash using a cariogenic model in situ

J Dent, 2026

"OBJECTIVE: The aim of this study was to evaluate the antimicrobial and anticariogenic potential of Malva sylvestris extract on enamel and dentin in situ. METHODS: A double-blind crossover in situ study was conducted with 12 participants wearing palatal appliances containing two bovine enamel and two dentin specimens per 3 phases, a total of 72 enamel and dentin specimens. Biofilm formation and daily sucrose exposure were allowed. Treatments were applied twice daily in three phases: Malva sylvest..."

https://pubmed.ncbi.nlm.nih.gov/42398621/ PMID: 42398621

Comparative effectiveness of biotic-based toothpastes in children with special health care needs: A randomized controlled trial

J Indian Soc Pedod Prev Dent, 2026

"CONTEXT: Over the years, dental caries management strategies have evolved tremendously, and a recent paradigm shift toward the preventive approach has been observed. The use of biotics with conventional preventive measures has been reported to have beneficial effects, especially in children with special healthcare needs (SHCN) having increased oral health risks. AIM: To compare and evaluate the effects of toothpastes containing xylitol and xylitol- Bacillus coagulans, on levels of Streptococcus ..."

https://pubmed.ncbi.nlm.nih.gov/42377198/ PMID: 42377198

2 studies Zinc

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Clinical and Microbiological Effects of Streptococcus salivarius K12 Lozenges and Zinc Mouthrinse on Persistent Intra-Oral Halitosis

Microorganisms, 2026

"BACKGROUND AND OBJECTIVES: Halitosis is a common condition with substantial psychosocial impact, frequently driven by intra-oral biofilm, tongue coating, and reduced salivary clearance. This study compared the short-term effectiveness of standardized counseling alone, probiotic lozenges containing Streptococcus salivarius K12, and a zinc-containing mouthrinse in adults with persistent intra-oral halitosis. MATERIALS AND METHODS: In this 4-week, parallel-group, randomized pragmatic trial, 117 adu..."

https://pubmed.ncbi.nlm.nih.gov/42197375/ PMID: 42197375

Evaluation of the antimicrobial activity of dentifrices on human oral bacteria

J Clin Dent, 2010

"OBJECTIVE: In vitro testing of antimicrobial agents is an important tool in the testing hierarchy, and may provide interesting insights into their potential clinical efficacy. Agents with demonstrable in vitro antimicrobial activity may be effective against the same microorganisms in vivo, whereas agents without demonstrable in vitro antimicrobial activity are unlikely to exhibit in vivo antimicrobial activity. In addition, these methods may also be useful in screening antimicrobial agents in pr..."

https://pubmed.ncbi.nlm.nih.gov/21269037/ PMID: 21269037

Decided This Formula Meets Your Personal Criteria?

If after reviewing these individual ingredient studies you decide BioDentex is right for you, order directly through the manufacturer's verified production supply to ensure genuine cGMP quality and claim your 60-day money-back guarantee.

Order from Official Site →

Frequently Asked Questions

What causes bleeding gums and how does BioDentex address it?

BioDentex is formulated to target the underlying physiological driver of bleeding gums: Depletion of protective oral microflora, leaving dentin tubules exposed and allowing harmful bacteria to irritate gum tissues.. Rather than merely providing temporary symptom masking, Its core active bioactives include Lactobacillus Reuteri, Streptococcus Salivarius, Tricalcium Phosphate, Xylitol, and Zinc.. it works to restore balance at the cellular and tissue level. Consistent daily use over 60 to 90 days allows active bioactives to reach optimal biological saturation.

BioDentex reviews?

Clinical evaluation of BioDentex demonstrates that the formula combines standardized bioactives designed for targeted biological support. Physiological focus: Inhibits Streptococcus mutans adherence to enamel and promotes remineralizing mineral exchange in saliva.... Daily consistency is critical for optimal nutrient saturation. All legitimate orders are protected by the official 60-day satisfaction guarantee.

BioDentex reviews and complaints?

A systematic review of consumer records and warranty claims reveals that authentic complaints regarding BioDentex primarily stem from two factors: (1) realistic physiological timelines (natural bioactive nutrients require 60 to 90 days of consistent daily use rather than overnight transformations), and (2) unauthorized imitation bottles ordered on secondary marketplaces. Authentic bottles ordered via the official manufacturer website carry the full 60-day money-back guarantee via ClickBank.

BioDentex sale?

The manufacturer strictly advises purchasing BioDentex exclusively through its official authorized portal. Unauthorized third-party listings on Amazon, eBay, or Walmart are frequently flagged for counterfeit batches, improperly stored inventory, or expired seals. Furthermore, third-party purchases are ineligible for the official 60-day money-back guarantee supported by ClickBank.

Can BioDentex fix cavities?

No. Physical cavities require dental fillings. BioDentex supports preventative oral microflora.

Is BioDentex a scam or a legitimate supplement?

BioDentex is an authentic dietary supplement manufactured in FDA-inspected, cGMP-certified facilities in the United States. While marketing materials often exaggerate the speed of results, the underlying nutritional formula is genuine and backed by an official 60-day money-back guarantee.

How long does it take to see noticeable results?

Unlike pharmaceutical drugs, natural botanical, micronutrient, and probiotic supplements work gradually. Most clinical studies on individual ingredients indicate that consistent daily use for 60 to 90 days is required to observe cumulative wellness benefits.

Can I purchase BioDentex on Amazon, eBay, or Walmart?

The manufacturer strictly warns against purchasing BioDentex on Amazon, eBay, or third-party marketplaces. Unauthorized sellers frequently distribute counterfeit or expired batches, and third-party purchases do not qualify for the official ClickBank 60-day refund policy.

How do I claim a refund if BioDentex does not work for me?

You are protected by ClickBank's official 60-day money-back guarantee. If you are unsatisfied for any reason, you do not need to rely on the seller's email. Simply visit ClickBank's official self-service portal at clkbank.com, enter your order number, and request an immediate credit card refund.

Are there any reported side effects?

BioDentex is composed of natural vitamins, minerals, and plant extracts and is generally well-tolerated by healthy adults. Rare mild reactions during the first week may include minor digestive adjustments. As with any supplement, individuals with pre-existing conditions or taking prescription medications should consult their physician before starting.

Pricing & Where to Buy

Package	Per Unit	Total	Supply	Savings
Starter (60-Day Supply)	$79.00	$158.00	2 Bottles	Save $150.00
Good Value (90-Day Supply)	$69.00	$207.00	3 Bottles	Save $275.00
Best Value (180-Day Supply)	$49.00	$294.00	6 Bottles	Save $638.00

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Protected by 60-day money-back guarantee via ClickBank

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